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Excess alcohol consumption during pregnancy could lead to fetal alcohol syndrome (FAS). However, the molecular mechanism leading to craniofacial abnormality, a feature of FAS, is still poorly understood. The cranial neural crest cells (NCCs) contribute to the formation of the craniofacial bones. Therefore, NCCs exposed to ethanol was investigated - using chick embryos and in vitro explant culture as experimental models. We demonstrated that exposure to 2% ethanol induced craniofacial defects, which includes parietal defect, in the developing chick fetus. Immunofluorescent staining revealed that ethanol treatment downregulated Ap-2ɑ, Pax7 and HNK-1 expressions by cranial NCCs. Using double-immunofluorescent stainings for Ap-2ɑ/pHIS3 and Ap-2ɑ/c-Caspase3, we showed that ethanol treatment inhibited cranial NCC proliferation and increased NCC apoptosis, respectively. Moreover, ethanol treatment of the dorsal neuroepithelium increased Laminin, N-Cadherin and Cadherin 6B expressions while Cadherin 7 expression was repressed. In situ hybridization also revealed that ethanol treatment up-regulated Cadherin 6B expression but down-regulated slug, Msx1, FoxD3 and BMP4 expressions. In summary, our experimental results demonstrated that ethanol treatment interferes with the production of cranial NCCs by affecting the proliferation and apoptosis of these cells. In addition, ethanol affected the delamination, epithelial-mesenchymal transition (EMT) and cell migration of cranial NCCs, which may have contributed to the etiology of the craniofacial defects.
San Antonio's first Chicken Salad Chick is ready to hatch. After months of planning and construction, the national chain of southern-style chicken salad restaurants has finally set an opening date for Alamo City's first installment in the Stone Oak area.
The chicken salad restaurant will open Wednesday, February 8, and the first 100 guests will receive a prize for their eagerness: one free large chicken salad every month for a year. Early birds will be happy to know that the Stone Oak Chicken Salad Chick will allow guests to start lining up at 7 a.m. that day.
Chicken Express serves up fried chicken, tenders and fish combo meals with sides ranging from fries to macaroni and cheese. Guests can pair those combos with a sweet tea or other drinks. Side note: Both restaurants' logos have speedy chickens on them.
Freshly fried chicken and your favorite mouth-watering comfort-food sides on-the-go! Fried chicken tenders and chicken dippers, fried fish, macaroni and cheese, mashed potatoes, potato wedges, and more. Oh- and don't forget to give #theRealCHAMP a try! Our premium chicken sandwich can take down all the other chicken sandwiches around. Try it.
Champs Chicken is redefining quality and convenience by serving up the best fried chicken at convenient locations all across the United States. We've got the most mouth-watering, make-grandma-proud fried chicken in town. Tenders, dippers, chicken sandwiches and all the heart-warming make-your-insides-feel-good sides to go with it! 041b061a72